Classic monster movies have cast a long shadow of the Castlevania series. From the original game finding representation for all the Universal Monsters of old (and referencing the actors that played those monsters, and the Hammer monsters as well, in the end credits), to continuing to borrow little elements here and there for later games, the Castlevania series acts not only as a solid action-platforming series but also a loving tribute to the classic horror.
It's easy to see a bit of that tribute, in a way, in the 1997 masterpiece, Castlevania: Symphony of the Night. Released just five years after the 1992 Dracula, this film borrows one key elements from that film: the death of Dracula's wife sends the warlord into a tailspin of madness and grief. Sure, while the details surrounding her death are different (an even better homage would come later in Lament of Innocence), you can see the sandbox the series is playing in.
Of course it also set up the fact that just about every wife, from this point forward in the series, will die. Once, maybe twice, sure, but it would have been better if Lisa were the only time the series dipped into this well. Sadly, it would happen many more times to come after this.
Castlevania: Symphony of the Night
For years, the vampire lord Dracula ruled over the land of Wallachia with a cruel, evil grip. He killed, he maimed, he tortured with impunity, especially against those he felt were attempting to steal his ancestral lands away. Many thought Dracula could never be redeemed, so the villagers all treated his castle as a no man's land, never to be approached lest you fail to return after.
But one woman, a local healer and alchemist, has heard about the powerful magics at Castle Dracula and sought to find out more for herself. This woman, Lisa, ventured to the castle to study, but she was met there by Dracula. Although he threatened and intimidated her, Lisa did not shy away. This caused Dracula to grow more than a little curious about the woman, so he let her explore his castle and study the magics within. Over time they grew close, and eventually were married.
In the years to follow, the happy couple welcomed a son into the world, the half-vampire Alucard, and the three lived as a happy family for years. But the shadow of evil never truly left Dracula in the minds of the villagers, and when they saw a woman living at the castle they assumed she was a witch. Her studied of magic, her ideas about alchemy and science certainly didn't help. Eventually, while Dracula was otherwise indisposed, the Church came to the Lisa's workshop and took her away in chains.
Her trial was laughably brief and soon Lisa was tied to a stake to be burned. As witnessed by her son, Alucard, Lisa pleaded for her son to not take his revenge, to not fight the humans, for while they were doing something stupid they didn't not fully understand what they were doing. These pleas were heard, and Alucard stood there while his mother died. Dracula did not take the news nearly as well, vowing revenge against all of mankind and launching his quest to rule the world and wipe humanity away. This led Alucard to stand against his father, respecting the wishes of his mother.
Years later, in 1797 AD, Alucard was summoned back to the castle due to an imbalance of good and evil he felt in the world. While exploring the castle he found himself lulled into a dream state, forced to witness the death of Lisa once more. This time, however, Lisa said for Alucard to kill the humans, to find his revenge against them. Alucard realized this couldn't be his mother, fighting off the dream, revealing it was all a ruse by the evil Succubus. They fought, and the dream demon was defeated, unable to lure Alucard to the side of evil.
In the end, when Alucard finally fought his way to the center of the castle to take on his father, it was the memories of his mother that drove him. The two battled, but once Dracula was defeated, they shared a memory of Lisa before Dracula begged for her forgiveness. He then was cast back to Hell to wait for his next resurrection, the evil inside he even then blotting out the memories of his loving wife.
Castlevania Netflix History:
Lisa (first named "Lisa of Lupu") appears in the Netflix Castlevania anime (voiced by Emily Swallow), making repeated cameo appearances throughout the series. The first episode of the first season documents the events of Lisa meeting Dracula: as a healer and scientist, Lisa goes to Castle Dracula in search of the knowledge housed within the castle's massive libraries. There she meets Dracula but instead of being afraid of him (as is the reaction from the rest of the villagers), she brave, wry, and confrontational. She calls him on his flaws, tells him he's been disconnected from the world, and then states that she'd like to help him in exchange for the use of his libraries. Intrigued by this strong, intelligent woman in his house, he agrees and the two strike up a friendship.
The show then cuts to twenty years later and Lisa (not "Lisa Tepes" and she and Dracula had married in the interim) had been captured by the Church and set to burn at the stake for her "witchcraft". It's not her marriage to Dracula that's the issue but her science and healing, matters that the Church declared verboten. She burns, but as she dies she pleads to the sky, hoping that Dracula would hear her words. "Don't blame them for they know not what they do!" Spoiler: Dracula blames them regardless.
In the second season we get a cut-back to this time period, where we witness the Church invade her home and workshop, declare her a witch, and then drag her from her home, burning it down in the process.
Along with her marriage to Dracula she also, of course, has a son: Adrian (aka Alucard). Alucard, it's later shown, was there to witness his mother's final words but, unlike his father, he takes heed of the words and sides against his father's plans to destroy humanity.
What the series does in the few early scenes is greatly flesh out he dynamic between Lisa and Dracula, making their relationship more compelling and shading his eventually anger and emotion over the loss of this extraordinary woman.
We then see her again near the end of the third season. She appears, in Dracula's arms, as the two are trapped in Hell. A portal is opened (by a hulking creature, the Visitor) leading right to Hell from the mortal world, and it's only through the actions of heroes Trevor Belmont, Sypha Belnades, and Saint Germain that the portal is closed, ensuring Dracula is unable to resurrect (at least at that time). Still, at least Lisa and Dracula were together, even if it was in Hell.
Appearing again, in Hell, in season four, Lisa and her husband are both targeted by Death and the minions of Dracula. Ostensibly to resurrect the Dark Lord, the real goal from the ancient soul-devouring vampire was to drag both Lisa and Dracula back into a single body, a rebis, using the darkest of magics. Within this single body the two souls would tear at each other and the torture would drive Dracula mad. The swath of carnage he wrought would feed Death for centuries.
Thankfully through the actions of the various heroes Death and his dark plans were thwarted. Although the souls of Lisa and Dracula were sucked into the body, and the agony they felt was intense, the foul rebis was quickly destroyed before the spell could be finalized. Their souls were freed as the rebis was torn asunder, and it was assumed that both Lisa and Dracula were cast back to Hell once more, at least free of the clutches of Death.
In reality, though, they were actually thrown back to Earth where the two of them found themselves free of past burdens, reunited once more. Venturing off into the countryside, Lisa and Dracula vowed to live peacefully together for a time, enjoying their company as the lived the life that had been snatched from them just a few years before. They eventually planned to reveal their existence to their son, Alucard, at some point in the future but hadn't by the time the series ended.